Prof. Dr. Md. Sharif Hossain
Prof. Dr. Md. Sharif Hossain Professor, Department of Biotechnology & Genetic Engineering

PROFILE

SHORT BIOGRAPHY

Dr. Md. Sharif Hossain has been serving as a Professor at the Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Jahangirnagar University, Dhaka, Bangladesh. He is dedicated to research and education for the breakthrough invention and advancement of life science technology from bench to clinic.

After completing his secondary and tertiary level education from Bangladesh, he moved to Japan and achieved his M.Sc. and Ph.D. degree from the Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology in 2008 and 2011 respectively as MEXT (The Ministry of Education, Culture, Sports, Science and Technology, Japan) scholar. He was then awarded Postdoctoral Fellowship of Japan Society for the Promotion of Science (JSPS) and conducted cutting edge research at Frontier Research Centre, Tokyo Institute of Technology, Japan (2011~2013). In 2014, he joined as Researcher at Biomaterials Centre for Regenerative Medical Engineering, Foundation for Advancement of International Science (FAIS), Tsukuba, Japan. By August 2014, he moved to Bangladesh and joined as an Assistant Professor at the Department of Biotechnology and Genetic Engineering, Jahangirnagar University. He also served as the chairman at the Department of Biotechnology and Genetic Engineering, Jahangirnagar University and successfully completed his tenure from July 2017 to July 2020.

Dr. Hossain’s research interest includes the field of Nanobiotechnology, Regenerative Medicine, Gene Therapy and Drug Delivery, Stem Cell Biology, Biomedical Engineering, Biomaterials Design,  Medical Biotechnology. He developed novel nonviral vector effective for cancer gene therapy and drug delivery. Moreover, he conducted cutting edge research to develop mammalian induced pluripotent stem (iPS) cell generation and guided differentiation for the regeneration of therapeutics cells. He also focused the influence of nano-biointerface on the intracellular regulation of stem cells (ES/iPS cells) for regenerative medicine and biomedical application. His current research focuses on the nanobiotechnology based approaches to overcome the challenges of antibiotic resistance. He has published more than 40 scientific articles including peer reviewed international journals, book chapters and international conferences papers.

He was the recipients of MEXT scholarship (The Ministry of  Education, Culture, Sports, Science and Technology, Japan) (2005~2011), Prestigious Fellowship of Japan Society for the Promotion of Science (JSPS) (2011~ 2013), Nucleic Acids Research Award (NAR Award) and Antisense (Kawahara) Award from Oligonucleotide Therapeutic Society, OTS (USA) (2009), Award of Excellence from Toin International Symposium on Biomedical Engineering, (Japan) (2007), Murakami Scholarship, Tokyo Institute of Technology, (Japan) (2008~ 2011), Bangladesh Education Leadership Award as Best Professor in Genetic Engineering Studies  from World Education Congress (2019).

RESEARCH INTEREST

Nanobiotechnology, Regenerative Medicine, Gene Therapy and Drug Delivery, Stem Cell Biology, Biomedical Engineering, Biomaterials Design, Medical Biotechnology.

JOURNAL PAPER

  1. Shanaz Fatema Bristy, Md. Reaz Uddin, Nowshin Jahan, Dewan Zubaer Islam, Bushra Ayat Meghla, Taslima Akter Tisha, Md. Aftab Uddin, Mohammad Tarequl Islam, Masayasu Mie, Eiry Kobatake, Mohib Ullah Khondoker, Taslin Jahan Mou, Md. Ahsanul Haq, Md. Fokhrul Islam, Zinia Islam, Md. Sharif Hossain, Nafisa Azmuda, Mohd. Raeed Jamiruddin, Susmita Sinha, Mainul Haque, Nihad Adnan, Misdiagnosis of Bacterial Pathogens by the Diagnostic Centers: A Potential Route for Antibiotic Resistance, Journal of Applied Pharmaceutical Science,p 001-011, Dec 14, 2023. DOI: 10.7324/JAPS.2024.175488 (Scopus Indexed)
  2. Chironjit Kumar Shaha, Bithy Sarker, Shurid Kishore Mahalanobish, Md. Sharif Hossain, Subarna Karmaker, and Tapan Kumar Saha Kinetics, Equilibrium, and Thermodynamics for Conjugation of Chitosan with Insulin-Mimetic [meso-Tetrakis(4-sulfonatophenyl)porphyrinato] oxovanadate (IV)(4−) in an Aqueous Solution, ACS Omega, October 2023  DOI: 10.1021/acsomega.3c05804 Impact Factor 4.1

  3. Israt Jahan Jhumi, Tusher-Al- Arafat, Polash Chandra Karmakar , Md. Arifuzzaman, Md. Sharif Hossain, Naznin Akhtar, S. M. Asaduzzaman, Silver Nanoparticle Incorporated Human Amniotic Membrane Gel Accelerates Second-Degree BurnWound Healing inWister Rat, Evidence-Based Complementary and Alternative Medicine, Volume 2023, p1-15, https://doi.org/10.1155/2023/9808556, Impact Factor 2.65

  4. Naznin Jahan, Tanvir Ahamed, Arun Das, Md. Arif Khan, Sharif Hossain, Satya Ranjan Sarker and Mohammad Mahfuz Ali khan Shawan, In Silico Subtractive Genomics Approach Characterizes a Hypothetical Protein (MG_476) from Microplasma Genitalium G37, Journal of Clinincal and Experimental Investigations, 13, 3, pp.1-10, 2022. doi: https://doi.org/10.29333/jcei/12377

  5. Md. Sabbir Ahmmed, Md. Maniruzzaman Sikder, Satya Ranjan Sarker,  Md. Sharif Hossain,  Razib Datta Shubhra, Nuhu Alam, First Report of Pseudopestalotiopsis theae Causing Aloe vera Leaf Spot Disease in Bangladesh, American Journal of Plant Sciences, Vol.13 No.2， February 18, 2022,   Impact Factor 1.17

  6. Razib Datta Shubhra, Shakil Ahmed Polash, Md. Monir Hossain, Amir Hamza, Md. Mehedi Hasan Tushar, Tanushree Saha, Md. Ashraful Hasan, Md. Maniruzzaman Sikder,Nuhu Alam, Zinia Islam , Md. Sharif Hossain, Satya Ranjan Sarker, Investigation of the Antimicrobial Activity and in Vivo Cytotoxicity of Diospyros malabarica (Desr.) Kostel. Fruit Extracts, Natural Science Vol.13 No.8，August 3, 2021, Impact Factor 2.3
  7. Bakul Akter, Ariful Islam Khan · Subarna Karmaker · Pollob Ghosh · Soma Saha · Shakil Ahmed Polash · Zinia Islam · Satya Ranjan Sarker · Md. Sharif Hossain · Hiroyuki Yasui · Tapan Kumar Saha, Chelation of zinc(II) with poly(γ‑glutamic acid) in aqueous solution: kinetics, binding constant, and its antimicrobial activity, Polymer Bulletin, https://doi.org/10.1007/s00289-020-03165-9 Received: 28 November 2019 / Revised: 2 March 2020 / Accepted: 10 March 2020, Impact Factor: 2.84
  8. Saiful Islam, Md. Ahsanul Kabir, Md. Faizul Hossain Miraz, Effat Jahan Tamanna, Satya Ranjan Sarker, Zinia Islam, S. M. Jahangir Hossain, Sharif Hossain*, Gautam Kumar Deb* (* Corresponding Author), Investigation of Ovarian Follicular Waves and Major Hormonal Profile in Red Chittagong Cattle, Advances in Bioscience and Biotechnology, 2020, 11, 7- 2. Impact Factor: 1.09

  9. Hossain MM, Polash SA, Takikawa M, Shubhra RD, Saha T, Islam Z, Hossain S, Hasan MA, Takeoka S, Sarker SR, Investigation of the Antibacterial Activity and in vivo Cytotoxicity of Biogenic Silver Nanoparticles as Potent Therapeutics, Front Bioeng Biotechnol. 2019 Oct 9;7:239. Impact Factor: 6.064

  10. Razib Datta Shubhra, Shakil Ahmed Polash, Tanushree Saha, Ashraful Hasan, Sharif Hossain, Zinia Islam*, Satya Ranjan Sarker* (* Corresponding Author), Investigation of the Phytoconstituents and Antioxidant Activity of Diospyros malabarica Fruit Extracts, Advances in Bioscience and Biotechnology, 2019, 10, 431-454. Impact Factor: 1.09

  11. Ratna Mondal, Shakil Ahmed Polash, Tanushree Saha, Zinia Islam, Md. Maniruzzaman Sikder, Nuhu Alam, Md. Sharif Hossain*, Satya Ranjan Sarker* (* Corresponding Author), Investigation of the Phytoconstituents and Bioactivity of Various Parts of Wild Type and Cultivated Phyllanthus emblica L., Advances in Bioscience and Biotechnology, 8, 211-227, 2017. Impact Factor: 1.09

  12. Shakil Ahmed Polash, Tanushree Saha, Md. Sharif Hossain and Satya Ranjan Sarker, Phytochemical contents, antioxidant and antibacterial activity of the ethanolic extracts of Centella asiatica (L.) Urb. leaf and stem, J U J. Biol. Sci., 2017 (June), 6(1): 51-57.

  13. Shakil Ahmed Polash, Tanushree Saha, Md. Sharif Hossain, Satya Ranjan Sarker, Investigation of the Phytochemicals, Antioxidant, and Antimicrobial Activityof theAndrographispaniculata Leaf andStem Extracts, Advances in Bioscience and Biotechnology, 2017, 8, 149-162. Impact Factor: 1.09

  14. Adnan N, Mie M, Haque A, Hossain S, Mashimo Y, Akaike T, Kobatake E., Construction of a Defined Biomimetic Matrix for Long-Term Maintenance of Mouse Induced Pluripotent Stem Cells, ACS Bioconjug Chem., 27(7):1599-605, July 20, 2016. Impact Factor: 6.069

  15. Haque A, Adnan N, Motazedian A, Akter F, Hossain S, Kutsuzawa K, Nag K, Kobatake E, Akaike T, An Engineered N-Cadherin Substrate for Differentiation, Survival, and Selection of Pluripotent Stem Cell-Derived Neural Progenitors, PLoS One, 10(8):e0135170, August 05, 2015. Impact Factor: 4.092

  16. Wu X, Yamamoto H, Nakanishi H, Yamamoto Y, Inoue A, Tei M, Hirose H, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Hossain S, Akaike T, Matsuura N, Doki Y, Mori M, Innovative delivery of siRNA to solid tumors by super carbonate apatite, PLoS One, 10(3):e0116022, March 04, 2015. Impact Factor: 4.092

  17. Sharif Hossain, Ezharul Hoque Chowdhury, Nihad Adnan and Toshihiro Akaike, Chapter Title: Biocompatible apatite nano-particles: A versatile tool for cellular delivery of genes, siRNAs, Drugs and proteins, Book Title: Apatite: Synthesis, Structural Characterization and Biomedical Applications, Nova Publishers, USA, August 2014.

  18. Juntaro Matsuzaki, Hidekazu Suzuki, Hitoshi Tsugawa, Mitsuhiro Watanabe, Sharif Hossain, Eri Arai, Yoshimasa Saito, Shigeki Sekine, Toshihiro Akaike, Yae Kanai, Ken-ichi Mukaisho, Johan Auwerx, Toshifumi Hibi, Bile Acids Increase Levels of microRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis, Gastroenterology, 145(6):1300-11, 2013 Dec. Impact Factor: 33.88

  19. Hossain S, Yamamoto H, Chowdhury EH, Wu X, Hirose H, Haque A, Doki Y, Mori M, Akaike T, Fabrication and intracellular delivery of Doxorubicin/Carbonate Apatite Nanocomposites: Effiect on growth retardation of established Colon Tumor, PLoS One, 8(4):e60428, 2013. Impact Factor: 4.092

  20. Hossain S*, Nag K*, (*equal contribution), Naznin S, Chowdhury EH, PKC activation promotes internalization of DNA-immobilized inorganic nano-crystals by clathrin-dependent endocytosis for efficient transgene expression in human lymphocytes, Journal of Nanomedicine and Nanotechnology, 4:174, 2013. Impact Factor: 3.57

  21. Sharif Hossain, Ezharul Hoque Chowdhury and Toshihiro Akaike, Chapter Title: Inorganic Nanomaterials of Carbonate apatite as intracellular nucleic acid/drug transporters, Book Title: Bioengineered Nanomaterials, Taylor & Francis Publisher, CRC PRESS, USA. August 2013. (BOOK CHAPTER)

  22. Stanislaus A, Bakhtiar A, Salleh D, Tiash S, Fatemian T, Hossain S, Akaike T, Chowdhury EH, Knockdown of PLC-gamma-2 and calmodulin 1 genes sensitizes human cervical adenocarcinoma cells to doxorubicin and paclitaxel, Cancer Cell Int., 12(1):30, 2012. Impact Factor: 5.99

  23. Hossain S, Chowdhury EH, Akaike T, Nanoparticles and toxicity in therapeutic delivery: the ongoing debate, Therapeutic Deliv., 2(2): 125-132, 2011. (EDITORIAL)Impact Factor: 2.12

  24. Haque A, Hexig B, Meng Q, Hossain S, Nagaoka M, Akaike T, The effect of recombinant E-cadherin substratum on the differentiation of endoderm-derived hepatocyte-like cells from embryonic stem cells, Biomaterials, 32(8): 2032-42, 2011. Impact Factor: 15.30

  25. Hossain S, Stanislaus A, Chua MJ, Tada S, Tagawa Y, Chowdhury EH, Akaike T, Carbonate apatite-facilitated intracellularly delivered siRNA for efficient knockdown of functional genes, J. Control. Release, 147(1): 101-108, 2010. Impact Factor: 11.46

  26. Hossain S, Tada S, Akaike T, Chowdhury EH, Influences of electrolytes and glucose on formulation of carbonate apatite nanocrystals for efficient gene delivery to mammalian cells, Anal. Biochem. 397: 156–161, 2010. Impact Factor: 3.19

  27. Hossain S, Akaike T, Chowdhury EH, Current approaches for drug delivery to central nervous system, Curr. Drug Deliv., 7（5）:389－397, 2010.Impact Factor: 3.75

  28. Kutsuzawa K, Tada S, Hossain S, Akaike T, Chowdhury EH, Disrupting actin filaments promotes efficient transfection of a leukemia cell line using cell adhesive protein-embedded carbonate apatite particles, Anal. Biochem. 388: 164 -166, 2009. Impact Factor: 3.19

  29. Sharif Hossain, Ezharul Hoque Chowdhury and Toshihiro Akaike. Efficient Delivery of siRNA by pH-Sensitive Inorganic Nanocrystals of Carbonate Apatite. Nucleic Acids Res., 37 (22): 7347-7348, 2009 Special editorial publication for award. Impact Factor: 19.16

  30. Afrin,N., Sikder,M.M., Hossain,M.S. and Shilpi,R.Y., Bacillus cereus strain JUB1 16S ribosomal RNA gene, partial sequence, GenBank Accession of bacterial sequences, GenBank: MH552993.1, 2018.

  31. Afrin,N., Sikder,M.M., Hossain,M.S. and Shilpi,R.Y., Bacillus cereus strain JUB2 16S ribosomal RNA gene, partial sequence, GenBank Accession of bacterial sequences, GenBank: MH552994.1, 2018.

  32.  Comments about my novel research: (from Editor in chief, Journal of Controlled Release) Park K. Carbonate apatite-facilitated intracellular delivery of siRNA. J Control Release. 147(1):1, 2010. Impact Factor: 11.46

CONFERENCE PAPER

  1. Sharif Hossain, and T. Akaike, pH-sensitive Nano-crystals of Carbonate Apatite for Smart and Efficient Drug/ transgene Delivery, Proceedings of the 40th Annual Meeting & Exposition of the Controlled Release Society (CRS), July 21 – 24, 2013, Honolulu, Hawaii, USA.
  2. S. Hossain and T. Akaike, Intracellular Regulation of ES/iPS Cells on E-Cad-Fc Engineered Matrix facilitated by Bio-functionalized Nanoparticles of Carbonate Apatite, Proceedings of the 3rd TERMIS World Congress 2012, September 5- 8, 2012, Vienna, Austria.(Journal of Tissue Engineering and Regenerative Medicine, Vol 6(1); 292-293, 2012).
  3. K. Arai, T. Adachi, S. Hossain, T. Akaike, M. Nakamura, Establishment of 3D culture system for primary hepatocytes, ‘Regulation of cell membrane polarity for tissue engineering’, Proceedings of the 3rd TERMIS World Congress 2012, September 5-8, 2012, Vienna, Austria.(Journal of Tissue Engineering and Regenerative Medicine, Vol 6 (1); 342-343, 2012).
  4. Sharif Hossain and Toshihiro Akaike, Novel pH-sensitive Carbonate Apatite Nanoparticles as Intracellular Gene/Drug Transporter, Proceedings of the 39th Annual Meeting & Exposition of the Controlled Release Society (CRS), July 15 – 18, 2012, Québec City, Canada.
  5. Sharif Hossain and Toshihiro Akaike, Bio-functionalized pH-sensitive Carbonate Apatite Nanoparticles Facilitated Intracellular Regulation of ES/iPS Cells on E-Cad-Fc Engineered Matrix, Proceedings of the 39th Annual Meeting & Exposition of the Controlled Release Society (CRS), July 15 – 18, 2012, Québec City, Canada.
  6. Sharif Hossain and Toshihiro Akaike, Design of super effective pH sensitive carbonate apatite nanoparticles as intracellular gene/drug transporter, 3rd Asian Biomaterial Congress, September15-17, 2011, Busan, Republic of Korea.
  7. Sharif Hossain, Ezharul Hoque Chowdhury and Toshihiro Akaike. Effective gene knockdown with carbonate apatite-facilitated intracellularly delivered siRNA, Proceedings of the 37th Annual Meeting & Exposition of the Controlled Release Society (CRS), July 10 – 14, 2010, Portland, Oregon, USA.
  8. Sharif Hossain and Toshihiro Akaike, Efficient Delivery of siRNA by pH Sensitive Nanocrystals of Carbonate Apatite, Proceedings of the 49th Annual Meeting of American Society of Cell Biology, from December 5-9, 2009, San Diego, California, USA.
  9. Sharif Hossain, Ezharul Hoque Chowdhury and Toshihiro Akaike. Efficient Delivery of siRNA by pH-Sensitive Inorganic Nanocrystals of Carbonate Apatite, Proceedings of the 5th Annual Meeting of Oligonucleotide Therapeutic Society and 19th Antisense symposium, November 3-6, 2009, Fukuoka, Japan.
  10. Sharif Hossain and Toshihiro Akaike, Design of an Efficient pH Sensitive Delivery System for Anticancer Drugs Based on Inorganic Nanocrystals of Carbonate Apatite, Proceedings of the 2nd TERMIS World Congress, August 31-September 3, 2009, Seoul, Republic of Korea.
  11. Sharif Hossain, Ezharul Hoque Chowdhury, and Toshihiro Akaike, Design of an efficient pH sensitive delivery system for anti cancer drugs based on inorganic nanocrystals of carbonate apatite, Proceedings of the 35th Annual Meeting & Exposition of the Controlled Release Society, July 12-16, 2008, New York, USA.
  12. Sharif Hossain, Ezharul Hoque Chowdhury, and Toshihiro Akaike, Design of a smart delivery system for anti cancer drugs based on inorganic nanocrystals of carbonate apatite, Proceedings of the 8th World Biomaterial Congress, May 28 – June 01, 2008, Amsterdam, The Netherlands.

BOOK CHAPTER

  1. Sharif Hossain, Ezharul Hoque Chowdhury, Nihad Adnan and Toshihiro Akaike, Chapter Title: Biocompatible apatite nano-particles: A versatile tool for cellular delivery of genes, siRNAs, Drugs and proteins, Book Title: Apatite: Synthesis, Structural Characterization and Biomedical Applications, Nova Publishers, USA, August 2014.
  2. Sharif Hossain, Ezharul Hoque Chowdhury and Toshihiro Akaike, Chapter Title: Inorganic Nanomaterials of Carbonate apatite as intracellular nucleic acid/drug transporters, Book Title: Bioengineered Nanomaterials, Taylor & Francis Publisher, CRC PRESS, USA. August 2013.

AWARD

AWARDS & HONORS:

  • Awarded Bangladesh Education Leadership Award as Best Professor in Genetic Engineering Studies  from World Education Congress 2019, Bangladesh.
  • Served as the Chairman at the Department of Biotechnology and Genetic Engineering, Jahangirnagar University, Bangladesh  and completed the tenure from July 2017 to July 2020.
  • Awarded Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship, JAPAN
  • Achieved the Nucleic Acids Research Award (NAR Award) and Antisense (Kawahara) Award from Oligonucleotide Therapeutic Society, OTS (USA), Link- http://www.oxfordjournals.org/our_journals/nar/award_winners.html, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794151/
  • Awarded Monbukagakusho Scholarship, Japan (Japan Embassy/Bangladesh Government Selection) from 2005-2011, Japan.
  • Received Award of Excellence for best presentation in Toin International Symposium on Biomedical Engineering 2007, in Yokohama, Japan.
  • Awarded Murakami Scholarship, Tokyo Institute of Technology (2008~ 2011), Japan.
  • Obtained University Distinction Marks  in the Bachelor of Science (B.Sc.) in Biotechnology and Genetic Engineering, Khulna University, Bangladesh.
  • Achieved Education Board Scholarship (Jessore Board) 1995, 1997, Bangladesh.
  • Obtained Primary and Junior Scholarship, Bangladesh.

 

SOCIETY ACTIVITY:

  • Controlled Release Society, USA(CRS)
  • TERMIS (Tissue Engineering International Regenerative Medicine Society)
  • Oligonucleotide Therapeutic Society, USA (OTS)
  • American Society of Cell Biology, USA (ASCB)
  • Japan Society of drug delivery system, JAPAN
  • Japanese Society for Biomaterials, JAPAN

 

LIST OF THE INTERNATIONAL SCIENTIFIC AND COLLABORATIVE MEETING ATTENDED

  • Tokyo Tech- McMaster University Collaborative Meeting, From July 14- 16, 2010, Hamilton, Ontario, Canada
  • Tokyo Tech- Mahidol University Joint Symposium, from July 31- August 2, 2008, Bangkok, Thailand.
  • The 3rd Scientific Meeting of the Asian Society for Vascular Biology, from August 4-5, 2008, Singapore city, Singapore

Contact

Prof. Dr. Md. Sharif Hossain

Professor
Department of Biotechnology & Genetic Engineering
Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
Cell Phone: +880 1758832428
Email: sharifhossain@juniv.edu

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